HMGCR and atherosclerosis: Statins, which inhibit 3-hydroxy-3-methylglutaryl co-enzyme A reductase (HMG-CoA reductase) are effective at reducing atherosclerosis and cardiovascular risks in clinical practice by lowering the levels low-density lipoprotein cholesterol (LDL-C) and total triglycerides (TG) [2–4].