One study evaluated the effect of the ABCB1 haplotypes (1236C>T, 2677G>A/T and 3435C>T) on TC and LDL-C responses to simvastatin and demonstrated a reduction in the T–non-G–T haplotype frequency in patients with myalgia compared with the non-ADR group (P = 03) [10]. This evidence concerns the gene ABCB1 and Myalgia.