ERBB2 and breast carcinoma: P-cadherin aberrant expression is associated with breast carcinomas of high histological grade, as well as with the expression of well established markers associated to poor patient prognosis, like Ki-67, EGFR, CK5, vimentin, p53 and HER-2, and negatively associated with the expression of hormonal receptors (ER and PgR) [53, 61–64].