Knockdown of P-cadherin in colon cancer cells inhibited wound healing, proliferation, and colony formation and resulted in developing fewer liver metastatic foci in vivo. The effect of P-cadherin inhibition was associated with the down-regulation of β-catenin (βctn) and its downstream target molecules, including survivin and c-Myc [71]. The gene discussed is CDH3; the disease is malignant colon neoplasm.