CDH3 and colon carcinoma: In fact, a novel and highly selective human monoclonal antibody against P-cadherin (PF-03732010, Pfizer) has demonstrated significant anti-tumour and anti-metastatic activities in distinct P-cadherin-overexpressing tumour models, which included breast, gastric, lung, prostate and colon carcinomas, without introducing any adverse secondary effects in mice [105, 106].