Autophagy is wildly involved in the tumorous development and drug resistance.[17–20] A recent study has found that ASPP2 inhibits RAS-induced autophagy by preventing ATG16/ATG5/ATG12 formation and induces autophagic apoptosis by releasing Beclin-1 from cytoplasmic Bcl-2-Beclin-1 complexes in hepatoma cells.[21, 22] However, the function and detailed mechanism of ASPP2 which regulate autophagy is still not clear, especially in pancreatic cancer. Here, TP53BP2 is linked to pancreatic neoplasm.