TP53BP2 and cancer: ASPP2 is a pro-apoptotic regulator that belongs to ASPP family.[10] The expression of ASPP2 is frequently suppressed in many cancers in relation to enhanced apoptosis through the binding to p53 for transcriptional transactivation.[11–15] Surprisingly, a number of ASPP2 binding partners that are involved in biological pathways other than apoptosis have also been identified,[10] suggesting that ASPP2 function is far more complex than simply enhancing p53-mediated apoptosis.