The capability of cancer cells to escape the cytotoxic effect of chemotherapeutic drug may result from genetic mutations that affect cell cycle, apoptosis or accumulation of drugs inside of the cell.[35, 36] In this study, we revealed the mechanisms by which pancreatic cancer cells to escape chemotherapeutic drug (gemcitabine) mediated cell apoptosis via decrease of ASPP2 expression to activate the autophagic activity. The gene discussed is TP53BP2; the disease is cancer.