Sub-sets of malaria patients either with or without histological evidence of PE were then examined using immunohistochemistry to investigate leukocyte sub-set localization (including CD3, CD8, CD68, and neutrophil elastase), the expression of bronchial IL-33, γ-ENaC, AQP-1 and -5, and pancytokeratin as a control. The gene discussed is IL33; the disease is malaria.