Anxiety-related behavior was observed in both 3-mercaptopyruvate sulfurtransferase knockout (3MST-KO)14 and TRPA1-KO mice15 as well as mice in which TRPA1 channels are pharmacologically inhibited15, suggesting the involvement of TRPA1 channels and 3MST in the induction of anxiety-like behavior. The gene discussed is TRPA1; the disease is Anxiety.