Therefore, the role of MVPA as a mediator might be due to it: improving insulin-mediated glucose uptake; improving insulin action by increasing GLUT-4 expression in skeletal muscles [37, 38]; reducing blood glucose and the risk of insulin resistance [39] and; inducing alterations in fatty acid partitioning within the muscle cells in insulin sensitivity [40]. This evidence concerns the gene SLC2A4 and Insulin resistance.