In fact, in less than 10 years since the first Dicer knockout study [50], several authors have reported the misregulation of specific miRNAs in mice models of different neurodegenerative disorders, which in some instances were confirmed in post mortem samples of the affected tissues (miR-206/miR-153 in Alzheimer’s disease [51,52]; miR-34b/miR-9/miR-9* in Huntington’s disease [53,54]; miR-9 in SMA [47]); miR-206/miR-338-3p/miR-451 in ALS [55,56]. The gene discussed is DICER1; the disease is proximal spinal muscular atrophy.