A recent study showed that the metabolite fucoxanthinol also prevents inflammation and insulin resistance by inhibiting NO and prostaglandin E2 (PGE2) production through the downregulation of both iNOS and cyclooxygenase-2 (COX-2) mRNA expression, which are related to the pathogenesis of inflammation, as well as adipokine secretion in WAT [39]. The gene discussed is PTGS2; the disease is Insulin resistance.