VEGFA and Familial prostate cancer: In vivo studies have shown that a diet rich in EPA and DHA, found principally in oily fish, has potent anti-angiogenic effects mainly in colon, breast and prostate cancers, inhibiting production of many important angiogenic mediators such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), platelet-derived endothelial cell growth factor (PDECGF), COX-2, PGE2, NO, NF-κB, MMPs and β-catenin [54].