A dolastatin obtained not from microalgae but from a marine mollusk (Dolastatin 15), along with the COX-2 inhibitor celecoxib, could prevent preneoplastic colonic lesions in a DMH-induced rat colon carcinogenesis model, through inhibition of NF-κB and iNOS [70], and it had anti-neoplastic effects in the same rat model through regulation of the phosphoinositide 3 kinase/Akt (PI3K/Akt) pathway [255]. The gene discussed is AKT1; the disease is digestive system neoplasm.