In microalgae, n-3 fatty acids-derived OXLs are produced from linoleic and α-linolenic acids and they have also shown a potent anti-inflammatory activity through decrease of inflammatory cytokines levels such as TNF-α [206] or amelioration of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats [207]. This evidence concerns the gene TNF and colitis.