An in vitro study on the colon adenocarcinoma cell line Caco-2 expressing GPR120 (G-protein coupled receptor with anti-inflammatory signaling properties after binding n-3 PUFAs) evidenced that EPA and DHA inhibited NF-κB activity and IL-1β secretion by activating ERK1/2 MAP kinase [50,197]. The gene discussed is NFKB1; the disease is colon adenocarcinoma.