Interestingly, patient ID–036 carried a novel large deletion involving the EPCAM-MSH2 genes, revealed by MLPA encompassing exon 3 of the EPCAM gene to exon 4 of MSH2. This patient displayed an aggressive phenotype with four primary tumors, including synchronous CRC at 44 years old, endometrial cancer at 45 and gastric cancer at the age of 50. The gene discussed is EPCAM; the disease is gastric cancer.