MSH2 and endometrial cancer: Interestingly, patient ID–036 carried a novel large deletion involving the EPCAM-MSH2 genes, revealed by MLPA encompassing exon 3 of the EPCAM gene to exon 4 of MSH2. This patient displayed an aggressive phenotype with four primary tumors, including synchronous CRC at 44 years old, endometrial cancer at 45 and gastric cancer at the age of 50.