CHEK2 and cancer: Since the majority of these 102 cells lines were profiled for mutations at panel of 1651 genes as part of the Cancer Cell Line Encyclopedia (CCLE) [46] we were able to identify 10 of the 102 as having either mutation or homozygous deletion of CHEK1 or CHEK2. Of note, none of the cell lines had RAD17 homozygous deletion, and RAD17 mutation status was not assessed in this dataset.