RAD17 and cancer: A recent pan-cancer analysis of all tumor exomes currently included in The Cancer Genome Atlas (TCGA)[40] found somatic mutations occur in RAD17 at an overall rate of 1.0% and homozygous deletions at a rate of 0.9%, which, given an annual incidence of approximately 1.7 million new cancer cases in the United States [41], equates to over 31,500 new patients per year with tumors involving RAD17 loss-of-function.