Previous studies have implicated a direct physical interaction between SPINK1 and EGFR; endogenous EGFR from cancer cell lysates was shown to coimmunoprecipitate with exogenous rSPINK1 [10, 13], and direct binding of EGFR extracellular domain to rSPINK1 was also demonstrated using a quartz-crystal microbalance technique [13]. This evidence concerns the gene SPINK1 and cancer.