SPINK1 and ovarian neoplasm: Also designated as tumor-associated trypsin inhibitor (TATI), SPINK1 was initially purified from the urine of a patient with serous ovarian adenocarcinoma [6]; very high concentrations of SPINK1 have also been observed in benign and malignant mucinous ovarian cyst fluids, with lower concentrations reported in cyst fluid from other ovarian tumor types [7].