Similarly, the association of CEMIP expression with poor prognosis in colon cancer was found in a different context by Birkenkamp-Demtroder et al. based on immunohistochemical studies in which a slightly better prognosis was reported for subgroup of stage II patients with strong nuclear, yet weak cytoplasmic, staining for CEMIP compared to cases with strong cytoplasmic, or nuclear and cytoplasmic staining [5]. Here, CEMIP is linked to malignant colon neoplasm.