CEMIP and neoplasm: Because remodeling of the extracellular matrix is crucial for aspects of tumor biology including tumor expansion, neovascularization, invasion, and metastasis [29], we tested if CEMIP mediated this function in colon cancers by histochemical staining for HA in the aggressive xenografts formed by CEMIP wild-type DLD1 colon cancer cells versus the impeded xenografts formed by CEMIP knockout cells.