CEMIP and malignant colon neoplasm: We originally identified KIAA1199 as a novel transcript highly induced in colon cancer and deposited the full-length transcript and 5′ UTR variants as GenBank accession numbers AY581148, AY585237, and AY581149, under the name Colon Cancer Secreted Protein 1 (CCSP1) before the gene name was officially changed to CEMIP. We found that CEMIP is markedly upregulated in colon cancer both at the mRNA and protein level, with induction occurring as early as the colon adenoma stage, and encodes a secreted protein (U.S. patent #7,118,912) [8].