RAC1 and colorectal carcinoma: A role in CRC metastases formation has been proposed for miR-320b, miR-320d and miR-1246.30, 31, 32, 33 MiR-320b was found to be upregulated in a recent study comparing miR expression profiles of CRC patients with and without liver metastasis.33 Overexpression of miR320b upregulates β-catenin (CTNNB1), Neurophilin 1 (NRP1) and Ras-related C3 botulinum toxin substrate (RAC1).