Strikingly, these two miRs were recently identified for having potential as circulating biomarker for early detection and screening of CRC.47, 48, 49, 50 Furthermore, both miR-92a and miR-21expression were shown to correlate with mCRC and regulate invasion and metastases by inhibiting phosphatase and tensin homolog.51, 52, 53 Five metastases-specific miRs were not represented in the 222 tumor-specific miRs, because for those miRs the difference in expression level between tumor tissue and adjacent normal tissue was not significant for both pCRC and metastases. The gene discussed is PTEN; the disease is neoplasm.