Thereby, miR-1246 might contribute to tumor angiogenesis.32 Downregulation of cell adhesion molecule 1 by miR-1246 enhances migration and invasion of hepatocellular carcinoma cell lines, further suggesting a role of miR-1246 in tumor metastases formation.31 When these miRs involved in the process of metastasis formation are further validated, therapeutic strategies can be developed that aim at the inhibition of the oncogenic miRs or reintroduction of the tumor-suppressive miRs. This evidence concerns the gene CADM1 and hepatocellular carcinoma.