PTEN and colorectal carcinoma: Strikingly, these two miRs were recently identified for having potential as circulating biomarker for early detection and screening of CRC.47, 48, 49, 50 Furthermore, both miR-92a and miR-21expression were shown to correlate with mCRC and regulate invasion and metastases by inhibiting phosphatase and tensin homolog.51, 52, 53 Five metastases-specific miRs were not represented in the 222 tumor-specific miRs, because for those miRs the difference in expression level between tumor tissue and adjacent normal tissue was not significant for both pCRC and metastases.