PIK3CA and familial pancreatic carcinoma: To determine whether the PIK3CA H1047R hotspot mutation initiates tumorigenesis in pancreatic cancers similar to that observed in Pc1Pik3cap110* mice, a total of 36 Pc1Pik3caH1047R mice were generated and necropsy was performed at 50, 150 and 250 day time points.