ERBB2 and neoplasm: For the first proof of principle, the created model was used for in vivo evaluation of anti-tumor efficacy of chemotherapeutic agent cisplatin and novel HER2-targeted recombinant immunotoxin based on the scFv fragment of Trastuzumab (4D5scFv) as a targeting module and fragment of Pseudomonas exotoxin A (ETA) as a toxic module.