AML cytogenetic subtypes Core-binding factor-AML  t(8;21)/RUNX1-RUNXT1  inv(16)/t(16;16)/MYH11-CBFbeta AML Acute promyelocytic leukemia t(6;9)AML Monosomal karyotype1 AML Intermediate-risk AMLBone marrow from healthy donors. The gene discussed is CBFB; the disease is acute promyelocytic leukemia.