We characterized these 60 trans-effect genes with annotated roles in cancer according to biological functions and found that 30/60 genes encode transcription factors (P value<0.001), 14/60 genes encode protein kinases (P value<0.001) and 4/60 genes (ATRX, BAP1, KDM5A, SETD2, P value<0.01) are chromatin regulatory factors. The gene discussed is SETD2; the disease is cancer.