Notably, critical roles of CD134L-CD134 and CD137L-CD137 interactions have been demonstrated in EAE36, 37, and an increased level of CD137L was detected in MS patients’ peripheral blood38, implying that the costimulatory ligands associated with Eomes induction in CD4+ T cells are present in the CNS lesions of EAE and MS. This evidence concerns the gene EOMES and myeloid sarcoma.