CEP152 and microcephalic primordial dwarfism: In this context, it is interesting to note that we may have identified a case of digenic inheritance of Seckel syndrome, pointing towards an additive genetic effect of mutations in CDK5RAP2 and CEP152. CDK5RAP2 and CEP152 are centrosomal proteins important for centrosomal cohesion and integrity (Bond et al.