BRCA1 and ovarian cancer: 2010; Vilar et al. 2011; Ledermann et al. 2014). In addition, clinical intervention such as salpingo-oophorectomy, which is undertaken in many women with BRCA mutations, may decrease cancer risk in probands and in their relatives with mutations (Munsell et al. 2006; Rebbeck et al. 2009). Therefore, breast and/or ovarian cancer patients without BRCA1/2 mutations should be screened using panel-based analyses for cancer prevention during routine medical checkups.