CD4 and peeling skin syndrome: In this study, we determined the levels of circulating CD4+CD161+ T cells and their “regulatory” (CD4+CD25+CD161+ T cell) and “effector” (CD4+CD25−CD161+ T cell) subpopulations in patients with pSS and analyzed the clinical significance of the CD4+CD161+ T cell subsets in pSS for the first time.