CD4 and peeling skin syndrome: For the effector or regulatory subpopulation of CD4+CD161+ T cells, higher frequency of IL-17-producing cells was also detected when compared with their CD4+CD161− counterpart in pSS patients (5.52 ± 2.28 versus 2.30 ± 0.99, p = 0.0058; 14.15 ± 7.95 versus 3.33 ± 1.96, p = 0.0169, Figure 1(a)).