Patients with thrombocytopenia, ANA positivity, increased ESR, elevated γ-globulin, or ESSDAI ≥ 4 showed higher proportions of CD4+CD161+ T (22.21 ± 10.69% versus 15.95 ± 6.95%, p = 0.013; 18.56 ± 8.71% versus 12.03 ± 4.33%, p = 0.043; 20.53 ± 9.35% versus 14.86 ± 6.48%, p = 0.012; 19.20 ± 9.49% versus 14.73 ± 5.36%, p = 0.026; 19.71 ± 9.77% versus 15.30 ± 6.18%, p = 0.049; Table 4, Figures 5(a)–5(e)). This evidence concerns the gene CD4 and Thrombocytopenia.