Increased TNF-α as a putative neuron-damaging molecule in the CNS is certain to be necessary for the development of experimental SCD in the totally gastrectomized rats, which was supported by the fact that intracerebroventricular microinjections of agents antagonizing TNF-α production largely prevented SCD-like lesions in the spinal cord white matter of the totally gastrectomized rats [7]. Here, TNF is linked to Schnyder corneal dystrophy.