Nevertheless, the differential expression of not only one but four different genes of HGF/MET system, the observed correlations between MET and SPINT1 mRNA expression and tumor histopathological features and the previous identification of MET as overexpressed in other metastatic pNETs [14] suggest the participation of the HGF/MET pathway in the later stages of insulinoma tumorigenesis. This evidence concerns the gene MET and pancreatic insulinoma.