EGFR and non-small cell lung carcinoma: More in details, they showed that gefitinib treatment reduces miR-30b/c and miR-221/222 expression levels, consequently leading to the upregulation of APAF and BIM, which are both involved in determining EGFR-TKIs-induced apoptosis in sensitive EGFR-mutant, HCC827, and PC9 NSCLC cell lines [73–74].