TP53 and cancer: The importance of miR-34 in cancer development was further strengthened by Kasinski and Slack who evaluated the feasibility of the delivery of miR-34 lentivirus in order to prevent cancer initiation and progression in a therapeutically resistant mouse model of lung adenocarcinoma harbouring KRAS LSL-G12D/+ and p53 LSL-R172H/+ mutations [81].