Taken together, these studies indicate that miR-30b/c and miR-221/222 upregulation in NSCLC determine resistance to EGFR-TKIs through the repression of APAF-1, BIM, and PTEN, while miR-103 and miR-203 induce apoptosis in EGFR-TKI resistant cells, also promoting mesenchymal to epithelial transition, by downregulating PKC and SRC. This evidence concerns the gene EGFR and non-small cell lung carcinoma.