EGFR and non-small cell lung carcinoma: Specifically, the most represented and better characterised are the so called classic mutations, which include in frame deletions in exon 19 in correspondence of the LeuArgGluAla sequence (E746-A750), and the exon 21 point mutation Leu858Arg (L858R), together representing 85%–90% of all EGFR mutations in NSCLC [25].