In the medical literature we found only one study on GSTM1 and GSTT1 gene polymorphisms and cardiovascular autonomic neuropathy (CAN) in T1DM in Slovak adolescents [30] but we did not find studies regarding these gene polymorphisms in T2DM DSPN. This evidence concerns the gene GSTM1 and Crouzon syndrome-acanthosis nigricans syndrome.