CHUK and Familial prostate cancer: Furthermore, phosphorylated form of IKKα/β was distributed both in the nuclear and cytosolic fractions of 4 human prostate cancer cells, where 22Rv1 and PC-3 cells exhibited high p-IKKα/β expression in the nuclear fraction as well as in the cytosol, compared to LNCaP and DU145 cells (Supplemental Figure 2).