CASP3 and neoplasm: Similar results were obtained in 22Rv1 tumors where apigenin intake resulted in 41% and 56% (P < 0.003) for p-IKKα/β; 16% and 37% (P < 0.005) decrease in positive stained cells; whereas 12% and 22% (P < 0.002) increase in cleaved caspase-3 stained cells in 22Rv1 tumor xenograft compared to the control group.