Given the role for IKKα-mediated NF-ĸB signaling in tumorigenesis and the IKKα activation in prostate cancer we provide in vitro experimental evidence that apigenin specifically binds with IKKα with higher affinity than IKKβ and blocks IKKα activation, which correlated with reduced migration of cancer cells treated with apigenin. Here, IKBKB is linked to prostate cancer.