As shown in Figure 9A & 9B, oral intake of apigenin at doses of 20 and 50 μg resulted in marked reduction in the protein expression of IKKα and its phosphorylation, NF-ĸB/p65 whereas a modest decrease in p-IKKβ in PC-3 and 22Rv1 tumor xenografts. This evidence concerns the gene RELA and neoplasm.