Although LY294002 and 15e (a PI3K inhibitor potently inhibits p100α activity) blocked AKT phosphorylation in most ABC subtype of DLBCL cells, both treatment had minimal effects on the growth, division, and apoptosis of OCI-Ly10 and some other ABC DLBCL cells except for HBL-1 and TMD8 cells [8]. The gene discussed is AKT1; the disease is diffuse large B-cell lymphoma.