Phosphorylation of extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (p-T202/Y204-ERK) by oncogenic forms of KRAS has also been associated with resistance to mTOR kinase inhibitors in colorectal cancer.30 HCT116 cells carry an oncogenic KRAS-G13D allele, but PAT4 knockdown did not reduce ERK phosphorylation (Figures 4c and d), suggesting that it does not act through ERK to regulate mTORC1. Here, SLC36A4 is linked to colorectal cancer.