The role of miR-194 has been analyzed in normal and malignant cells of the gastrointestinal tract as high levels of miR-194 are expressed in the intestine and liver.22, 23 Reduced miR-194 expression was noted in CRC.24 An increased miR-194 expression in differentiating Caco-2 colon cancer cells has been reported.25 In this regard, we have noted decreased levels of SPRY2 during spontaneous Caco-2 cell differentiation (unpublished observation). This evidence concerns the gene SPRY2 and malignant colon neoplasm.