We have demonstrated upregulation of SPRY2 protein in a small number of matched control CRC samples.5 Our results were supported by a study which showed upregulation of SPRY2 in undifferentiated high-grade tumors and at the invasive front of low-grade carcinomas.9 However, another study revealed reduced SPRY2 transcripts in human colon cancer.7 The reported differences in the level of SPRY2 transcript and protein may account for posttranscriptional and translational regulation of SPRY2 in CRC. The gene discussed is SPRY2; the disease is malignant colon neoplasm.