On the other hand, Willems-Jones et al. [42] note that high-grade prostatic intraepithelial neoplasia, believed to be a precursor to prostate adenocarcinoma in some cases, does not display LOH at the mutation locus in BRCA2 mutation carriers with aggressive prostate cancer. The gene discussed is BRCA2; the disease is prostate intraepithelial neoplasia.