As BRCA1 and BRCA2 are involved in the repair of DNA double-strand breaks (DSBs), a process called homologous recombination, dysfunctional BRCA could render a tumor hypersensitive to drugs that (ultimately) induce DNA DSBs during the DNA replication phase, such as the PARP inhibitors or alkylating chemotherapy. Here, BRCA1 is linked to neoplasm.