GCLM and schizophrenia: DTI studies in schizophrenia patients have also revealed alterations in other cortical and subcortical WM structures (Ellison-Wright and Bullmore, 2009; Segal et al., 2010; Abdul-Rahman et al., 2011; Lee et al., 2013; Canu et al., 2014; Holleran et al., 2014) that were not significantly altered in the brain of Gclm KO mice.