Further evidence comes from the cyst inflation being slowed down either through pharmacological inhibition of CFTR or by reducing its apical expression in cyst-lining cells (Blazer-Yost et al., 2010; Li et al., 2004, , 2012; Yang et al., 2008; Yuajit et al., 2013, , 2014). This evidence concerns the gene CFTR and cyst.