CFTR and cyst: Numerous studies using cellular (Li et al., 2004, , 2012; Reif et al., 2011; Yuajit et al., 2013) or mouse models for ADPKD (Blazer-Yost et al., 2010; Yang et al., 2008; Yuajit et al., 2014) have proved the key role of CFTR in the cyst inflation process.