CFTR and autosomal dominant polycystic kidney disease: The role of CFTR in ADPKD has been approached using in vitro cellular models such as Madin–Darby canine kidney (MDCK) cells (Li et al., 2004, , 2012; Yuajit et al., 2013) and ADPKD cyst-derived cell lines (Reif et al., 2011).