In more than 75 % of cases, EBS is caused by mutations in the KRT5 and KRT14 genes, affecting keratin 5 (K5) or keratin 14 (K14), respectively (Bolling et al. 2011); however, mutations in nine other genes were reported to cause the EBS phenotype (Fine et al. 2014). The gene discussed is KRT14; the disease is epidermolysis bullosa simplex.