For example, methylated RASSF1A was significantly related with the risk of death for STS patients [6]; high serum osteopontin is correlated with poor prognosis in STS [7]; Brownhill et al. have advocated use of the proliferation index (by detecting Ki-67) in a risk model of outcome for Ewing’s sarcoma [8]. This evidence concerns the gene SPP1 and telomere syndrome.