Analysis of RECK alternative transcripts expression in astrocytomas of different malignant grades (II, III and IV/GBM) by qRT-PCR, revealed that, although RECK-I apparently was not modulated during astrocytoma progression, RECK-B displayed lower expression levels in GBM, when compared to grade II astrocytomas, a similar pattern to that of the canonical transcript, but with a more variable expression distribution within each tumor grade. The gene discussed is RECK; the disease is neoplasm.