bcl-X codes for a pro- (Bcl-XS) and an anti- (Bcl-XL) apoptotic form, while VEGF codes for both pro- (VEGF-XXX) and anti-(VEGF-XXXb) angiogenic isoforms [46–50] Interestingly, when the ratio of canonical RECK expression/RECK-B was analyzed, GBM patients presenting higher expression of RECK according to this ratio presented longer overall survival, suggesting that RECK isoforms balance influence over GBM biology and disease outcome should be explored. The gene discussed is VEGFA; the disease is glioblastoma.