ESR1 and neoplasm: We then analyzed the effects of these SNPs on a series of disease characteristics in the patient cohort, including lymph node metastasis, tumor size, tumor grade, clinic stage, and the status of estrogen receptor (ER) or progesterone receptor (PR), HER2, P53, Ki67, and intrinsic subtypes (Luminal A, Luminal B, HER2-positive, and Triple-negative) (Supplement Table 2).