We hypothesized that common variants in other genes in the FGF pathway might also raise breast cancer risk, and we carried out this case-control study to identify associations between breast cancer risk and common variants in the FGF receptor genes FGFR3 and FGFR4 by genotyping selected tag-SNPs in women from Heilongjiang Province, northeast of China. The gene discussed is FGFR4; the disease is breast cancer.