The results showed that the minor allele of rs1966265 and rs351855 in the FGFR4 gene were strongly associated with breast cancer in Chinese women of Heilongjiang Province, with ORs of 1.335 (95%CI = 1.154-1.545) and 1.364 (95%CI = 1.177-1.580), respectively. The gene discussed is FGFR4; the disease is breast cancer.