ESR1 and metastatic malignant neoplasm in the lymph nodes: We then analyzed the effects of these SNPs on a series of disease characteristics in the patient cohort, including lymph node metastasis, tumor size, tumor grade, clinic stage, and the status of estrogen receptor (ER) or progesterone receptor (PR), HER2, P53, Ki67, and intrinsic subtypes (Luminal A, Luminal B, HER2-positive, and Triple-negative) (Supplement Table 2).