Indeed, inhibition of CDCP1 expression via KAI1/CD82 in an in vivo tumor xenograft model, leads to significantly decreased levels of hypoxia-inducible factor-1α (HIF-1α) and one of its key down-stream targets, the angiogenesis promoting protein vascular endothelial growth factor-1 (VEGF-1) [72]. This evidence concerns the gene CD82 and neoplasm.