It was discovered that in both prostate cancer DU145 and colon cancer HT29 cell models, NDRG1 over-expression significantly decreased Src phosphorylation at Tyr416, while it had no significant effect on Src phosphorylation at Tyr527 or total c-Src levels (Figure 6A) [156]. Here, NDRG1 is linked to Familial prostate cancer.