CHI3L1 and infectious otitis media: AOM/DSS treatment in the Brp39 KO BM -> WT BMT-chimeric mice resulted in a BW profile that is intermediate between WT and Brp39 KO mice, suggesting that the CHI3L1 expression in the non-hematopoietic cells, presumably IECs, can partially ameliorate colitis (Figure 1A).