CHI3L1 and colitis: Conversely, the Brp39 KO BM-> WT mice displayed a histological profile that is intermediate between WT and Brp39 KO mice (Figure 1C, 1D, 1E), suggesting again that the CHI3L1 expression in the non-hematopoietic cells, in particular in IECs, partially protect mice from colitis exacerbation, presumably through IEC survival and restitution.