In vivo, colonic sections from AOM/DSS treated WT mice clearly displayed strong nuclear localization of STAT3, β-catenin as well as NF-κB, whereas Brp39 KO mice predominately exhibited a cytoplasmic staining pattern of these transcriptional factors (Figure 5B and Supplementary Figure 4). The gene discussed is NFKB1; the disease is infectious otitis media.