To investigate pathways differentially regulated between cluster C2 and the other clusters, we performed GSEA and discovered that cluster C2 was exclusively enriched for signatures of hepatocellular carcinomas that harbor CTNNB1 mutations in the two following datasets: BOYAULT_LIVER_CANCER_SUBCLASS_G6_UP (p < 10−10, FDR < 10−6) (Figure S1) and CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_UP (p < 10−10, FDR = 0.004) (Figure S2). This evidence concerns the gene CTNNB1 and hepatocellular carcinoma.