COPE and neoplasm: According to their expression levels, hit genes can be classified in three groups: 1) genes with significantly high overexpression in PTC vs normal thyroid: CCND1, RGS3, OXTR, RASD1, DNM3; 2) genes with equal or slightly different expression in PTC and normal thyroid: COPE, COPZ1, PLA2G15, SRPK1, REM2, EPHB4, BRAF; 3) genes that are significantly downregulated in PTC vs normal thyroid: MAP4K5, NUDT9, MASTL. No differences among different PTC variants (classical, follicular, tall cell) or tumor stage were observed (data not shown).