The papillary thyroid carcinoma BCPAP cell line, carrying the BRAFV600E mutation, and the immortalized normal human thyrocyte Nthy-ori 3–1 cell line were transfected with a siRNA library containing 25139 siRNA oligos targeting about 9000 potentially “druggable” genes (3 duplexes/gene, on average), and with a non-targeting siRNA (siNT) and a siRNA targeting the proteasomal subunit PSMC3 as negative and positive controls, respectively. The gene discussed is PSMC3; the disease is thyroid gland papillary carcinoma.