KLF4 and head and neck carcinoma: Consistent with a survival role for KLF4 in certain epithelial cell tumors, KLF4 induces squamous epithelial cell dysplasia when expressed in basal keratinocytes in mice [69], transforms rat kidney epithelial cells in vitro [70], and is correlated with bad prognosis when over-expressed in human head and neck carcinomas [47,71].