In addition, though it seems to be paradoxical to link caspase 3, an execution molecule of cell apoptosis, with proangiogenic response, there have been accumulating studies clarifying diverse growth-promoting effects of caspase 3, such as fibrosis [34], osteoclastogenesis [32], tissue regeneration [35], oncogenic transformation [36] and tumor repopulation [15]. Here, CASP3 is linked to neoplasm.