We showed activated Protease-activated receptor-1 (PAR1), which is a G-protein coupled receptor (GPCR) and activated when thrombin cleaves the amino-terminal extracellular domain at a specific site, promoted cell invasion and induced Snail mediated E-cadherin transcriptional repressor and ultimately EMT in gastric cancer cells [21, 22]. Here, F2R is linked to gastric cancer.