IFNG and neoplasm: Similar effect was observed on the expression of effector molecules in purified CD8+ T cells from the pooled spleen and LN of 4T1HA tumor-bearing mice treated with bortezomib (Figure 2A), which also showed increased expression of the high-affinity IL-2 receptor α-chain, CD25, along with increased intracellular secretion of IFNγ (Figure 2B).