Using murine renal and mammary solid tumors expressing a low-avidity model antigen hemagglutinin (HA) [45], or a lung fibrosarcoma expressing human Ras and mutant human p53 as xenogeneic antigens [46], we investigated the effects of bortezomib on the lymphocyte expression of activation and effector molecules during an endogenous anti-tumor T cell response in tumor-bearing mice and explored their underlying mechanisms. Here, TP53 is linked to neoplasm.