In conclusion, this immunohistochemical study shows that AdipoR1, adiponectin, Ob-R, leptin, aromatase, COX-1, COX-2, PGF2α, F2-isoprostanes and α-SMA are expressed and localised on higher levels in the breast tissues adjacent to the tumor compared to tumor specimens when considering either score or staining area whereas AdipoR2, leptin and COX-2 were also found on staining intensity and Ki67 on score level in the tumor tissue. This evidence concerns the gene LEP and neoplasm.