A second study showed that ZNF217 transduction into SV40 Tag/tag expressing, p53/pRB-deficient, human ovarian surface epithelial cells (named IOSE cells) promoted neoplastic progression associated with telomerase activity, anchorage independence, genomic changes and aberrant gene-expression levels similar to those observed in ovarian carcinomas [35]. This evidence concerns the gene ZNF217 and ovarian carcinoma.