By simultaneously targeting various arms of Bcl-2 regulation (as shown in Figure 5D), we were able to synergistically induce apoptosis in bulk, CD34+CD38−, and CD34+ proliferating and quiescent progenitor cells from samples obtained from patients with BC CML even when cells were not sensitive to a single agent or co-cultured with MSCs. The gene discussed is BCL2; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.