RNLS and lobular neoplasia: The area under the ROC curve (Fig 2B) of serum renalase as a marker for active LN was 0.906 (95% CI: 0.830–0.981, P<0.001) with the cutoff point of 66.67 μg/ml, the sensitivity and specificity for distinguishing active and inactive LN were 87.5% and 89.2%, respectively.